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To combat rising violent crimes, the Police Chief asks Detective Oh Goo Tak to form a team consisting of criminals. He is currently suspended from the police force for using excessive force. He then gathers team members: Park Woong Chul who is a gangster, Lee Jung Moon who is the youngest serial killer with extraordinary intelligence and Jung Tae Soo who is a contract killer. Police Inspector Yoo Mi Young also joins the team and she tries to have these guys work as a team by dealing with them rationally and sometimes emotionally.
The Cartel follows ten friends, all of them members of a dangerous drug cartel, whose ambition for power and money will cause them to eventually kill each other. For it is an undeniable truth that, in this business, you always lose.